Overview

Atmofix-OZ is used to treat infections caused by bacteria. It works as an antibiotic by stopping the growth of bacteria and also killing it.It is used to treat infections such as bronchitis, gonorrhea and infections of ear, throat, tonsils etc. Ornidazole is a drug that cures some protozoa infections and prophylaxis of anaerobic bacterial infections and Cefixime inhibits an enzyme transpeptidase which is responsible for bacterial cell walls synthesis.

Indications

• Tonsillitis
• Pharyngitis
• Otitismedia
• Bronchitis
• Urinary tract infections
• Gonorrhea
• Infections caused by susceptible organisms.

Pharmacology

PHARMACODYNAMIC PROPERTIES OF CEFIXIME

Cefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall.Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime.It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria.

PHARMACOKINETICS OF CEFIXIME

Absorption: Absorbed up to 50 %
Distribution: widely distributed
Metabolism: A portion of drug is metabolized in the body.
Excretion: Excreted mainly through urine

PHARMACODYNAMIC PROPERTIES OF ORNIDAZOLE

It is a nitro imidazole derivative, antiprotozoal antibiotic, Antimicrobial.

MECHANISM OF ACTION OF ORNIDAZOLE:

Ornidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization & strand breakage has been observed.

PHARMACOKINETICS OF ORNIDAZOLE

Absorption: Well absorbed.
Distribution: Widely distributed
Metabolism: Metabolized in liver by conjugation
Excretion: Excreted in urine and small portion is excreted in bile

Contraindications

Hypersensitivity to cephalosporins

Along with carbamazepine

Pseudo membranous colitis

Precautions

Special Precautions should be taken while taking Cefixime in case of renal impairment. Also patients allergic to peniciilins should be careful while taking cefixime. Use cautiously along with salicylates & Probenecid. Use with caution during pregnancy and old aged patients. Contraindicated during breast feeding.

Special Precautions while taking Ornidazole in cases of ailments like Vertigo, Mental confusion and Ataxia. Use with caution in pregnancy and it is contraindicated during the First trimester of Pregnancy. Use with caution in old age patients as well as children.

Side Effects

Very rare but the common side effects are:

Abdominal pain

Vertigo

Nausea

Vomiting

Fatigue

Dry mouth

Headache