Composition
- Each Liquid Contains:
- Oxethazaine BP
10 mg
- Dried Aluminium Hydroxide IP
0.291 g
- Magnesium Hydroxide IP
(in A Sorbitol Base Q.S)98 mg
Packing
- 170ML (64)
(Without Carton)
MRP
- 78
Overview
Oxetacaine is a potent local anesthetic. It is an amide anesthetic that is stated to have prolonged action. It is administered by mouth in conjugation with antacids; aluminum hydroxide and magnesium hydroxide, for symptomatic relief of pain associated with peptic ulcer disease (gastro-esophageal reflex disease).
Indications
- Gastro-esophageal reflex disease
- Peptic ulcer
- Relief pain associated with hemorrhoids
- Local anesthetic
- Gastric/duodenal ulcer
- Stomach discomfort
- Heart burn in late pregnancy
- Hyperacidity
- Eructation
Contraindications
Antacid containing aluminum hydroxide is contradicted in patients having low level of phosphate in blood (Hypophosphatemia) due to phosphate binding property of aluminum salt.
Contradicted in sever renal impairment.
Side Effects
Constipation
Rash
Thirst
Diarrhea
Headache
Anorexia
Weakness
Sleepiness
Vertigo
Dosage
Oral:
Disclaimer:To be taken only after consulting with the doctor.
Storage
Keep bottle tightly closed in a cool place.
Pharmacology
Mechanism of Action
Oxetacaine produces reversible loss of sensation by preventing the conduction of sensory nerve impulses near the site of application. This acts by decreasing the permeability of the sodium ions across the membrane (membrane stabilizing effect). In stomach it increases the pH and neutralizes the gastric acid, which relieves the hyperacidity problems.Aluminum hydroxide and magnesium hydroxide react chemically to neutralize the existing quantities of acid by forming a coating over the inflamed mucosa but have no effect on production of gastric acid. Antacid also thickens the liquid to help carry the Oxetacaine and coat the food pipe.
Pharmacokinetics
Onset of Action: 5 minutesDuration of Action: 2-3 hours
Pharmacodynamics
Oxetacaine is a topical potent anesthetic.Combining Oxetacaine with aluminum hydroxide exerts a prolonged topical anesthetic action. The antacid neutralize stomach acid and prevents further irritation of the food pipe.Interactions
The rate and extant of absorption of certain drugs may be increased or decreased. Therefore give medicine at least 1 to 2 hours before or after a dose of this liquid. Drugs that could be affected:
- Digoxin
- Benzodiazepines
- Phenothiazines
- Tetracycline
- Phenytoin
- Ionized
- Ethambutol
- Vitamin A
- Iron salt