Composition
- Each Capsule Contains:
- Rabeprazole IP
20 mg
- Itopride SR
150 mg
Packing
- 5X3X10(Shrink 5 Box)
(Alu-Alu)
MRP
- 115
Overview
Rabeprazole and Itopride Combination is used in the treatment of irritable bowel syndrome. This Medicine Improves Gastric Motility, Gastro-Duodenal Coordination And Thus Helps In Smooth Emptying Of Stomach.
Indications
- Active Duodenal ulcer
- Benign Gastric ulcer
- Zollinger- Ellison syndrome
- Erosive Gastroesophageal reflux disease
Pharmacology
Pharmacodynamics Properties of Rabeprazole:
Rabeprazole prevents the production of acid in the stomach. It reduces symptoms and prevents injury to the esophagus or stomach in patients with gastroesophageal reflux disease (GERD) or ulcers. Rabeprazole is also useful in conditions that produce too much stomach acid such as Zollinger-Ellison syndrome. Rabeprazole may also be used with antibiotics to get rid of bacteria that are associated with some ulcers. Rabeprazole is a selective and irreversible proton pump inhibitor, suppresses gastric acid secretion by specific inhibition of the H+, K+ -ATPase, which is found at the secretory surface of parietal cells. In doing so, it inhibits the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen.Pharmacokinetics Properties of Rabeprazole:
Absorption: Rabeprazole sodium is well absorbed after oral administration and its bioavailability is about 50% since it undergoes first pass metabolism.Distribution: It is widely distributed in the body in protein bound form.
Metabolism: Rabeprazole sodium is extensively metabolised in the liver.
Excretion: It is excreted mainly in the urine and small amount in faeces.
Pharmacodynamics Properties of Itopride:
Itopride has three way action. It inhibits the dopamine D2 receptor at the parasympathetic nerve ends.It increases the release of acetycholine and decreases the metabolism of acetylcholine by inhibiting the enzyme acetylcholinesterase (AChE). By maintaining higher acetylcholine levels, itopride increases the oesophageal and gastrointestinal peristalsis, increases the lower oesophageal sphincter pressure, stimulates gastric motility, accelerates gastric emptying and improves gastro-duodenal coordination. Itopride exerts anti-emetic actions because of its dopamine D2 receptor antagonistic action at CTZ.Pharmacokinetics Properties of Itopride:
Absorption: it is orally well absorbed after oral administration.Metabolism: Itopride undergoes extensive hepatic metabolism
Side Effects
Very rare but the common side effects are:- Diarrhea
- Abdominal pain
- Headache
- Constipation
- Irritated feeling
- Giddiness
Contraindications
- Hypersensitivity to Rabeprazole sodium
- Gastrointestinal haemorrhage
- Mechanical obstruction or perforation