Overview

Ofloxacin and Metronidazole Suspension is used for the treatment, control, prevention of diarrhoea and dysentery. Ofloxacin is a fluoroquinolone antibiotic used for treating certain kinds of bacterial infections. It kills bacteria by preventing them from reproducing and repairing themselves. Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa. Metronidazole is an antibiotic, amebicide, and antiprotozoal.It kills other microorganisms in addition to bacteria by damaging the DNA. Together, they treat our infection effectively.

Indications

Ofloxacin & Metronidazole Suspension is used for the treatment, control, prevention, & improvement of the following conditions and symptoms:

• GI infections
• Soft Tissue Infections
• Stomach Infection
• Diarrhea
• Inflammatory bowel syndrome and UTI's

Contraindications

It should not be taken if you have the following conditions:

Hypersensitivity To Quinolones

Uncorrected Hypokalaemia

Storage

Keep in a cool, dry and dark place.
SHAKE WELL BEFORE USE

Side Effects

Headache

Nausea

Dryness in mouth

Headache

Pharmacology

Ofloxacin stops the production of bacteria by inhibiting the repair and reproduction of their genetic material (DNA). Metronidazole enters the cells of microorganisms that contain nitroreductase, where its nitro group is reduced. Unstable intermediate compounds are formed which bind to DNA and inhibit synthesis, causing cell death.

Pharmacodynamics

Pharmacodynamic Properties of Ofloxacin:
Ofloxacin Is A Fluoroquinolone Which Inhibits Bacterial Topoisomerase IV And DNA Gyrase Enzymes Required For DNA Replication, Transcription, Repair And Recombination. It Has Activity Against A Wide Range Of Gram-Negative And Gram-Positive Microorganisms.

Pharmacodynamic Properties of Metronidazole:
Metronidazole is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa.It is selectively absorbed by anaerobic bacteria and sensitive protozoa, the metronidazole metabolites are taken up into bacterial DNA, and form unstable molecules. This function only occurs when metronidazole is partially reduced, and because this reduction usually happens only in anaerobic cells, it has relatively little effect upon human cells or aerobic bacteria.

Pharmacokinetics

Pharmacokinetic of Ofloxacin:
Absorption: Rapidly And Well Absorbed From The GI Tract.
Distribution: Widely Distributed Into Body Fluids, CSF, Tissues, Bile (High Concentrations); Crosses The Placenta And Enters Breast Milk.
Protein-Binding:20-32%.
Metabolism: Hepatic
Excretion: It is excreted in the urine by tubular secretion and glomerular filtration (75-80% as unchanged, <5% as metabolites); via faeces (4-8%).

Pharmacokinetic of Metronidazole
Absorption: Metronidazole is readily absorbed.
Distribution: Metronidazole is widely distributed. It appears in most body tissues and fluids. It also crosses the placenta and rapidly enters foetal circulation.
Protein-Binding: No more than 20% is bound to plasma proteins.
Metabolism: Metronidazole is metabolised in the liver by side-chain oxidation and glucuronide formation. The plasma elimination half-life of metronidazole is about 6-9 hours; that of the hydroxy metabolite is slightly longer.
Excretion: It is excreted in the urine, mainly as metabolites; a small amount appears in the faeces.

Pregnancy & Lactation

Pregnant and lactating women should take this medication only under the prescription of the physician.