Overview

Diacerein is a slow-acting drug taken as a pill that may slow the breakdown of cartilage and relieve pain and swelling.

Indications

This medication is an anti-inflammatory agent, prescribed for osteoarthritis and chronic inflammatory arthritis. It works by inhibiting interleukin-1.

Warnings

Caution should be exercised in patients with history of liver, kidney disease, during pregnancy and breastfeeding.

Monitor complete blood count, liver function, and urinalysis regularly while taking this medication.

Contraindications

Hypersensitivity.

Side Effects

Diarrhea, stomach pain, nausea, vomiting and intense yellow coloring of urine.

Dosage

Oral:
Disclaimer:To be taken only after consulting with the doctor.

Storage

Store it at room temperature (25 to 30°C), and in an airtight container.

Pharmacology

Mechanism of Action

Diacerein is an antirheumatic drug. It produces its action by inhibiting Interleukin-1. It is a disease modifying anti-rheumatoid drug used in the treatment of Osteoarthritis and chronic inflammatory arthritis. Diacerein is a slow-acting, symptom-modifying and disease-structure modifying drug for osteoarthritis. In arthritis the cartilage that protects the ends of the bones breaks down and causes pain and swelling. Diacerein may slow down the breakdown of cartilage and relieve pain and swelling.

Pharmacokinetics

Diacerein is an anthraquinone derivative that has been used in osteoarthritis. It is thought to act via inhibition of interleukin-1Β.

Interactions

Decreased absorption with aluminium and/or magnesium hydroxide antacids. Increased risk of diarrhoea with laxatives, antibiotics. Avoid co-admin with fibres and phytates.