Composition
- Each Tablet Contains:
- Glucosamine Sulphate
500 mg
- Methyl Sulphonyl Methane
50 mg
- Diacerein
50 mg
Packing
- 5X3X10
(Shrink 5Bx)
MRP
- 180
Overview
Atmoflex-GM Plus comprises of Glucosamine Sulphate , Methyl Sulphonyl Methane and Diacerein which is used treat
osteoarthritis and protect the ends of the bones break down, which can lead to swelling and pain. Glucosamine and Diacerein
are proteoglycan synthesis stimulators while Methyl Sulfonyl Methane (MSM) is a nutritional supplement. Together, they help
in the building of cartilage (the soft tissue around the joints) leading to joint repair. MSM additionally lowers inflammation
(swelling) of the joints. Glucosamine Sulphate help in the structure and function of joints and also support in osteoarthritis.
Diacerein support the breakdown of cartilage and alleviate the inflammation and ache. Methylsulfonyl Methane (MSM) is used to
treat chronic pain, wrinkles, joint inflammation,osteoporosis, bursitis,tenosynovitis, musculoskeletal pain, scar tissue,
muscle cramps.
Indications
- To reduce pain and swelling of the joints caused by osteoarthritis.
- Support the structure and function of joints.
- Stimulate the formation of collage.
- Stimulate joint function and repair.
- Joint inflammation, rheumatoid arthritis, osteoporosis, bursitis, tendonitis, tenosynovitis.
Contraindications
- Hypersensitivity to the active substance or any of the excipients.
- NSAIDs are contraindicated in patients who have previously shown hypersensitivity reactions (e.g. asthma, rhinitis, angioedema, or urticaria) in response to ibuprofen, aspirin, or other non-steroidal anti-inflammatory drugs.
- Nausea
- Constipation
- Indigestion
- Diarrhoea
- Urine discolouration
- Heartburn
- Precaution should be taken in patients with - GI disease; renal or hepatic impairment; alcohol-dependent patients; asthma or allergic disorders; hemorrhagic disorders; hypertension; cardiac impairment.
- Elderly: Monitor renal and hepatic function and blood counts during long term treatment.
Side Effects
Pharmacology
Pharmacodynamics
Pharmacodynamics Properties of Glucosamine Sulphate:
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Glucosamine provides natural building blocks for growth, repair and maintenance of cartilage. Glucosamine may lubricate joints, help cartilage retain water and prevent its breakdown.
Methyl Sulphonyl Methane:
Methylsulfonylmethane is a sulfur-containing compound. MSM helps in inhibiting the secretion of cytokines (IL-6 and TNF-α) and COX-2 induction in response to lipopolysaccharide.
Diacerein:
Diacerein is an anthraquinone derivative. Two mechanisms of action of Diacerein have been validated: in vitro inhibition of interleukin-1 (IL-1) synthesis, the main cytokine involved in cartilage destruction, and activity on the synthesis of proteoglycans, and hyaluronic acid, the principal component of cartilage.
Pharmacokinetic Properties Of Glucosamine Sulphate
Absorption: Well absorbed,bioavailability is low due to first-pass hepatic metabolism~26% The gastrointestinal
absorption is close to 90%.
Distribution: It is not protein-bound, but rather incorporates into plasma proteins (primarily globulins).
Metabolism:-Liver, extensive
The first-pass effect in the liver in which more than 70% of glucosamine is metabolized.
Elimination: Excreted through urine.
Methyl Sulphonyl Methane:
Absorption:Paracetamol is readily absorbed from the gastrointestinal tract.
Distribution: Peak plasma concentrations occur about 10 to 60minutes after oral doses. Paracetamol is distributed
into most body tissues. It crosses the placenta and is present in breast milk. Plasma-protein binding is negligible at usual
therapeutic concentrations but increases with increasing concentrations.
Metabolism:It is metabolized in the liver.
Elimination:It is excreted in the urine, mainly as the glucuronide and sulfate conjugates. The elimination half-life
varies from about 1 to 4 hours.
Diacerein:
Absorption:It is orally absorbed.
Distribution: It is distributed mainly in protein bound form.
Metabolism:It undergoes metabolism in the liver.
Elimination:It is excreted mainly through urine.
Precautions and Warnings:
Pregnant And Lactating:
Pregnant and lactating women should take this medication only under the prescription of the physician.