Overview

Dry syrups are the mixtures that require the addition of water at the time of dispensing inadequate chemical stability of drug in aqueous vehicle to avoid the physical stability problem.

Cefixime is in a group of drugs called cephalosporin antibiotics. Cefixime is used to treat many different types of infections caused by bacteria. Your symptoms may get better before the infection is completely treated. Cefixime will not treat a viral infection such as the common cold or flu.
It has been demonstrated by recent studies that Cefixime shows significantly better symptoms relief with the modest improvement of bacterial infection.

Indications

It is used to treat number of Bacterial infections including:

• Urinary tract infections caused by Escherichia coli and Proteus mirabilis.
• Otitis media caused by Haemophilus influenza.
• Onsillitis caused by S. pyogenes.
• Uncomplicated gonorrhea caused by Neisseria gonorrhoeae.

Contraindications

Cefixime is contraindicated for use in the following conditions:

Caution when used during pregnancy.

Caution when used during lactation.

Hypersensitivity to cephalosporin.

Side Effects

Side effects of cefixime are most likely to be minor:

Mild nausea

Stomach pain

Constipation

Headache.

Pharmacology

Mechanism of Action

Like all beta-lactam antibiotics, cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall , thus causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefixime interferes with an autolysin inhibitor.

Pharmacodynamics

Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.

Interactions

BEFORE TAKING THIS MEDICINE TELL THE DOCTOR ABOUT ANY MEDICAL PROBLEMS AN ALLERGIES THAT CHILD HAS NOW OR HAS HAD.
Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications. Probenecid may increase the serum level of cefixime.