Overview

Ferrous Ascorbate: This medication is an iron supplement used to prevent or treat low levels of iron in the blood due to anemia or during pregnancy . Iron is an important mineral that the body needs to produce red blood cells and keep you in good health , iron is made from animal hemoglobin (part of the blood). In the body, iron becomes a part of hemoglobin and myoglobin. Hemoglobin carries oxygen through your blood to tissues and organs. iron is used for iron deficiency anemia.
Folic acid also known as folate or Vitamin B9.Folic acid is indicated for the treatment of megaloblastic anaemia because of the folic acid deficiency. It is also used for prophylaxis in chronic haemolytic states, in renal dialysis, and in drug induced folate deficiency.Folic acid is used for the prevention of recurrence of neural tube defects.
Folic acid is a vitamin which we use to prevent or treat a deficiency of folic acid in the body. Folic Acid 5mg Tablets is used in the treatment and prevention of certain types of anaemia a low red blood cells. Adequate amounts of vitamin B12 need to be given along with folic acid. Folic acid Tablets can also be given to some women before and during pregnancy to prevent spina bifida an abnormality of the spine in babies, which can be caused by deficiency of this vitamin.

Indications

Ferrous Ascorbate is an iron supplement used to prevent or treat low levels of iron in the blood due to anemia or during pregnancy where as Folic acid is used for the treatment of megaloblastic anaemia because of folic acid deficiency. It is also used for prophylaxis in chronic haemolytic states, in renal dialysis, and in drug induced folate deficiency

About Composition

Mechanism of action:

Ferrous Ascorbate, Hemoglobin carries oxygen through your blood to tissues and organs. Myoglobin helps your muscle cells store oxygen. It is used to treat iron deficiency.  Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase (DHFR). These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.

Pharmacodynamics:

Ferrous Ascorbate The major activity of supplemental iron is in the prevention and treatment of iron deficiency anemia. Iron has putative immune-enhancing, anticarcinogenic and cognition-enhancing activities.
Pharmacodynamics of folic acid is as follows ,the mucosa of the duodenum and upper part of the jejunum are rich in dihydrofolate reductase, where folates and folic acid are absorbed. Once it is absorbed, folic acid is rapidly reduced and then methylated to form tetrahydrofolic acid derivatives which are rapidly transported to the tissues

Pharmacokinetics:

Ferrous Ascorbate is a naturally sourced from Iron derived from bovine hemoglobin and is highly available for absorption. Absorption:Iron is readily absorbed throughout the small intestine and is absorbed better than any other form of Iron. This is a mineral that is important nutrient to human life and health.Iron is a mineral essential for good health. The body uses iron to manufacture hemoglobin, which is the protein found in red blood cells that carries oxygen throughout the body. Without an adequate quantity of iron, it may be at risk for iron deficiency anemia, with its accompanying symptoms that include fatigue, dizziness or light-headedness, headache, insomnia, shortness of breath on exertion, and pallor. Iron Supplement Tablets are an excellent source for helping the body maintains healthy iron levels
Folic acid is readily absorbed following oral dosage, and is extensively bound to plasma proteins.
Absorption: Folic acid is absorbed rapidly from the small intestine and primarily absorbed from the proximal portion. Naturally occurring folates are reduced enzymatically to folic acid in the gastrointestinal tract prior to absorption. Folic acid appears in the plasma approximately 15 to 30 minutes after an oral dose; peak levels are generally reached within 1 hour.
Distribution: Tetrahydrofolic acid derivatives are distributed to all body tissues but primarily stored in the liver.
Metabolism: Folic acid is metabolized in the liver into the cofactors dihydrofolate DHF and tetrahydrofolate THF , by the enzyme dihydrofolate reductase (DHFR).
Elimination: After a single oral dose of 100 mcg of folic acid in a limited number of normal adults, only a trace amount of the drug appeared in the urine. Approximately 50% of the dose appearing in the urine. After intake of single oral dose of 15 mg, up to 90% of the dose was recovered in the urine. A majority of the metabolic products appeared in the urine after 6 hours; excretion was generally completes within 24 hours. Small amounts of orally administered folic acid have also been recovered in the feces. In lactating mothers folic acid is also excreted in the milk .

Contraindications

Hypersensitivity to the active substance.

if someone have iron overload disorders hemochromatosis, hemosiderosis

Patients having malignant disease, unless megaloblastic anaemia due to folic acid deficiency

Pregnancy and breast-feeding: If you are pregnant, planning to become pregnant or if you are breast feeding, then concern doctor for advice before taking any medicine

Side Effects

Common side effects include

flushing

nausea, loss of appetite

bloating in stomach

bitter and unpleasant taste in your mouth

sleep problems

depression

Constipation

Diarrhea

stomach/abdominal cramping

Iron may cause your stool to turn black, an effect that is not harmful.