Overview

Atmocreas is a combination of two medicines: Pancreatin and Activated Dimethicone. Pancreatin is a digestive enzyme that helps in digestion of fatty food. Pancreatin is made up of the pancreatic enzymes trypsin, amylase, and lipase. Trypsin hydrolyses proteins to oligopeptides, amylase hydrolyses starches to oligosaccharides and the disaccharide maltose and lipase hydrolyzes triglycerides to fatty acids and glycerols. Pancreatin is an effective enzyme for replacing missing pancreatic enzymes used in several essential body processes. Activated Dimethicone is a mixture of polydimethylsiloxanes and silicon dioxide, is an antifoaming agent which disintegrates gas bubbles & allows easy passage of gas and carminative.

Indications?

• Indigestion
• Loss of Appetite
• Stomach Fullness
• Bloating
• Flatulence
• Hepatic and biliary dysfunction
• Hereditary pancreatitis

Warning & Precaution

Consult your doctor or pharmacist before taking this combination if:

You are allergic to any of this ingredients

You are hypersensitive.

You are pregnant or planning to be become pregnant

You have liver disease.

Contraindications

It should not be taken if you have the following conditions : Gastrectomy, Hypersensitivity, Pancreatectomy.

Side Effects

Very rare but the common side effects are:

Hypotension

Headache

Tachycardia

Nausea

Vertigo

Dosage

Oral:
Dosage based on the condition as directed by the physician.

Pharmacology

Pharmacodynamics:

Pharmacodynamics Properties of Pancreatin

Pancreatin is made up of the pancreatic enzymes trypsin, amylase, and lipase. The trypsin hydrolyzes proteins to oligopeptides, amylase hydrolyses starches to oligosaccharides and the disaccharide maltose, and lipase hydrolyzes triglycerides to fatty acids and glycerols. Pancreatin is an effective enzyme for replacing missing pancreatic enzymes used in a number of essential body processes. Pancreatin is given to people who do not produce enough enzymes to digest their food properly.

Pharmacodynamic Properties of Activated Dimethicone:

Dimethicone acts by decreasing the surface tension of gas bubbles, thus facilitating their coalescence and expulsion as flatus or belching. It also prevents the formation and accumulation of mucus-enclosed pockets of gas in digestive tract. Dimethicone also facilitates the passage of gas through bowel lumen and allows patients to excrete a greater volume of gas at one time, thereby reducing the number of flatus events. Antiflatulents are added to an antacid gum coating to be effective antigas materials and eliminate trapped gas. The most common antigas material is Dimethicone and when mixed with silicone dioxide becomes Simethicone. Simethicone is also referred to as activated Dimethicone, is the most common antigas material and may be the only drug approved antiflatulent. The active antacid and antiflatulent in the gum coating is released into the saliva and ingested to give relief from gastrointestinal disturbances in the gastro-intestinal tract. Activated Dimethicone helps to relieve pain and bloating caused by trapped wind.Â

Pharmacokinetics:

Pharmacokinetics Properties of Pancreatin:

Absorption: Actively absorbed from gastrointestinal tract in an ionized form; and vitamin D in its active form is required for calcium absorption.
Distribution: Through the portal circulation, it reaches liver and is distributed to the body fluids.
Metabolism: It is digested Metabolism starts in the small intestine as it is converted to polypeptides and then to amino acids and finally into urea.
Excretion:It excreted in urine and faeces.

Pharmacokinetics Properties of Activated Dimethicone:

Absorption:Not absorbed.
Distribution:Dimethicone is pharmacologically inert and is not absorbed from the gastrointestinal tract or to interfere with gastric secretion.
Metabolism: The drug is not absorbed and it is excreted in the feces unchanged.
Excretion: Excreted unchanged in feces.

Interactions

• Antacids that contain calcium or magnesium : may reduce pancreatin activity. Don’t administer together.
• Products that contain iron:Decreases absorption of these drugs.Monitor patient for decreased effectiveness.