ATMOCLIF-SR Tablets

Composition
  • Each Film Coated Sustained Release Tablet Contains:
  • Aceclofenac IP
    200 mg

Packing
  • 10x10
    (Blister)
MRP
  • 55

Overview

Aceclofenac belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). These drugs have anti-inflammatory and painkiller properties.
Aceclofenac works by blocking the production of hormone-like substances called prostaglandins. Prostaglandins are released at the sites of injury, tissue damage and immune reactions. Prostaglandins play an important role in both the inflammatory response of the body and stimulating the re-absorption of bone in diseases.

Indications

This medication is a nonsteroidal anti-inflammatory drug (NSAID), prescribed for fever, pain, ankylosing spondylitis and arthritis. It blocks the action of a substance in the body (cyclo-oxygenase), which may cause pain, swelling and inflammation. It blocks the action of a substance in the body (cyclo-oxygenase), which may cause pain, swelling and inflammation.

Warning

Caution should be exercised in patients with history of Crohn's disease, bruising, heart, liver, or kidney disease, gastrointestinal disease, blood clotting problems, systemic lupus erythematosus, elderly, during pregnancy, alcohol-dependent patients, and breastfeeding.
It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

Contraindications

Contraindicated in patients with severe ulcer, gastrointestinal bleeding, and hypersensitivity.

Side Effects

Diarrhea, nausea, headache, indigestion, heartburn, abdominal pain, flatulence, feeling sick, dizziness and rash.

Dosage

Oral:
Disclaimer:To be taken only after consulting with the doctor.

Storage

Store it in an airtight container in a cool dry place. Protect from light.

Pharmacology

Mechanism of Action

Aceclofenac, a phenylacetic acid derivative, has antiinflammatory and analgesic properties. It is a potent inhibitor of cyclo-oxygenase which is involved in the production of prostaglandins.
Absorption: Well absorbed from the GI tract (oral); peak plasma concentrations after 1-3 hr.
Distribution: Protein-binding: 99%.
Excretion: Urine (as hydroxymetabolites); 4 hr (elimination half-life).

Interactions

May increase plasma concentrations of lithium and digoxin. Increased nephrotoxicity when used with diuretics or ciclosporin. Monitor serum potassium when used with potassium-sparing diuretics and ACE inhibitors. May enhance activity of anticoagulants. May increase risk of methotrexate toxicity when administered within 24 hr of methotrexate admin. Increased risk of GI bleed with other NSAIDs. Increased risk of convulsion with quinolones.