Composition
- Each Uncoated Tablet Contains:
- Aceclofenac IP
100 mg
- Paracetamol IP
325 mg
- Serratiopeptidase IP
10 mg
Packing
- 10x10
(Alu-Alu)
MRP
- 90
Overview
his combination offers the advantage of the peripheral effects of aceclofenac, the central effect of paracetamol and pain relief with the tissue repair effects of serratiopeptidase for pain management.
What is Atmoclif-Forte and What it is Used For?
Atmoclif-Forte is a combination of Aceclofenac, Paracetamol & Serratiopeptidase. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti- inflammatory, analgesic, and antipyretic activities. Paracetamol, also known as Acetaminophen, is commonly used for its analgesic and antipyretic effects. Serratiopeptidase is a proteolytic enzyme (protease) produced by Enterobacterium Serratia sp. E-15 used in the prevention of pain and swelling.Atmoclif-Forte is used in adults and children to treat the following infections:
- For relief of mild to moderate pain.
- Pain and fever due to upper respiratory tract infections.
- Spondylitis
- Back and Joint Pain.
- Headache
Contraindications
Patients sensitive to aceclofenac, paracetamol & serratiopeptidase.
Contraindicated in patients with severe ulcer gastrointestinal bleeding and hypersensitivity.
Aceclofenac and Serratiopeptidase is contraindicated in patients with asthma, renal or hepatic disorders, hypertension and porphyria.
Side Effects
Atmoclif-Forte ( Aceclofenac, Paracetamol and Serratiopeptidase) may cause side effects.
Diarrhea
Upset stomach
Vomiting
Mild skin rash
Dosage
Oral:
Disclaimer:To be taken only after consulting with the doctor.
Pharmacology
Mechanism of Action
Aceclofenac, a phenylacetic acid derivative, has antiinflammatory and analgesic properties. It is a potent inhibitor of cyclo-oxygenase which is involved in the production of prostaglandins.
Absorption: Well absorbed from the GI tract (oral); peak plasma concentrations after 1-3 hr.
Distribution: Protein-binding: 99%.
Excretion: Urine (as hydroxymetabolites); 4 hr (elimination half-life).
Pharmacokinetics Properties
Aceclofenac:
Absorption-
After oral administration, aceclofenac is rapidly and completely absorbed as
unchanged drug. Peak plasma concentrations are reached approximately 1.25-
3.00 hours following ingestion.
Distribution-
Aceclofenac penetrates into the synovial fluid, where the concentrations reach
approximately 57% of those in plasma. The volume of distribution is
approximately 25 L. Aceclofenac is highly protein-bound (>99%). Aceclofenac
circulates mainly as unchanged drug.
Metabolism-
4'hydroxyaceclofenac is the main metabolite detected in plasma.
Elimination-
The mean plasma elimination half-life is around 4 hours. Approximately twothirds
of the administered dose is excreted via the urine, mainly as
hydroxymetabolites.
Paracetamol:
Absorption-
Paracetamol is well absorbed by the oral route. The plasma half-life is about 2
hours.
Distribution-
Plasma protein binding is negligible at the usual therapeutic concentration, but
increases with increasing concentrations. Acetaminophen is, relatively, uniformly distributed throughout most body fluids. The plasma half-life is (t1/2) 2-3 hours
and the effect after an oral dose lasts for 3-5 hours.
Metabolism-
Paracetamol is primarily metabolized in the liver by conjugation to glucuronide
and sulphate. A small amount (about 3-10% of a therapeutic dose) is
metabolized by oxidation and the reactive intermediate metabolite thus formed is
bound preferentially to the liver glutathione and excreted as cysteine and
mercapturic acid conjugates.
Elimination-
Excretion occurs via the kidneys. Of a therapeutic dose, 2-3% is excreted
unchanged, 80-90% as glucuronide and sulphate, and a smaller amount as
cystein and mercapturic acid derivatives.
Serratiopeptidase:
Absorption-
After oral administration, serratiopeptidase is almost totally absorbed from the
gastrointestinal (GI) tract.
Distribution-
Serratiopeptidase binds to alpha-2 macroglobulin in the blood and produces an
enzyme activity in the blood circulation. It shows a steep rise in concentration at
the site of injury and inflammation.
Metabolism-
Metabolism of serratiopeptidase takes place in the liver.
Excretion-
The metabolites of serratiopeptidase are excreted through the urine and faeces.