Overview

Betamethasone dipropionate with gentamicin gives combine action as anti-inflammatory, antipruritic and vasoconstrictor with the broad spectrum anti-bacterial effect of gentamicin.

Indications

• It is used in asthmatic attacks
• Used to treat eczema
• Jock itch
• Athlete's foot
• Use to treat candidiasis
• Wound healing
• Psoriasis

About Composition

Bechlomethasone:

Bechlomethasone propionate is a corticosteriod used for relief of itching , redness and inflammation associated with variety of skin conditions such as allergic dematitis , contact dermaitis , psoriasis .

Gentamicin Sulfate:

Gentamicin Sulfate is a wide spectrum antibiotic that is used to treat primary and secondary bacterial infections of the skin or in infected seborrheic dermatitis.

Clotrimazole:

Clotrimazole is imadazole derivative and broad spectrum antifungal drug . It is used to treat fungal and yeast infection caused by athlete's foot , in ringworm infection , jock itch .

Mechanism of Action

Bechlomethasone:

is a corticosteroid used to help relieve redness, swelling, itching, and other discomfort of fungus infections. It may work by increasing the transcription of genes coding for anti-inflammatory proteins, including lipocortin-1 and interleukin-10. Corticosteroids suppress the multiple inflammatory gene expression by promoting histone deacetylation, resulting in tighter coiling of DNA and reduced access of transcription factors to their binding site. It has anti-inflammatory activity and can suppress the immune system. Corticosteroids can also stop skin cells from growing and multiplying.

Clotrimazole:

it inhibits fungus growth by inhibiting the division. It alters the permeability of the fungal cell wall by inhibiting the biosynthesis of ergosterol and other sterols required for cell membrane production that eventually leads to cell death. It also inhibits the activity of enzymes within the cell.

Gentamicin Sulfate:

it works by"irreversibly" binding to specific 30S-subunit proteins and 16S rRNA leads to misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic proteins which ultimately kills the cell.